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Hi everyone. Help needed with 6A please Deranged worrier keeps London guide as sharp deterrent (5 4) I have ???o? w?r?

Anag 'worrier' + A-Z

Thanks scorpiojo. I did think it was an anagram but couldn't get the 2 missing letters. Do you have any hints for 1D? BY and large not one to be macho. WIth your help I have ?a???

1d 6-letter word for "by and large" minus i (one)
Def. macho

As I like to be pedantic, I must say 2 Down is an elected member, not an official.

Can I have a clue please for 8A: Pop to operate remote button ?A?S?
Thanks.

pop = father

Thanks dagnabit. It makes sense now. My internet connection has been frozen for ages!

Very late to this, but there were a few I didn't like this week.

23 "one short" for "take off last letter" is rather loose.
2d someone has already mentioned; for me they aren't homophones either!
17d (to be pedantic) "Medical sign" is not the same as the answer - doctors (my wife is one) make a distinction between "signs", which are what they find by examining the patient, and the answer, which is what the patient tells them about how he/she feels.