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"immediately after new work, finish off, retiring"

U - O -

100% sure of the U and the O

Can only be "upon" meaning immediately after?

I can see it could be N for new and OP for work in reverse (retiring?) but can't see where the U comes in

work=opu(s)

Hmm. Has to be, I suppose. I've come across "op" as an abbreviation for opus a hundred times, but never "opu". And I still can't see why "retiring" should mean reversing.

Maybe it's just a crap clue.

It's "work, finish off" - i.e. take the last letter off OPUS

http://cryptics.wikia.com/wiki/List_of_reversal_indicators

Ah, that does make more sense. Many thanks.