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hello I am stuck on 46d Keratinous growth, I searched on Wikipedia to no avail. I have t.....l I know tumour but doesn't fit
And depart from the usual course of action 49 across 4 words 4 2 3 4 the first starts with s the second ends in t the next is likely to be of second letter of 4th word would be glad of any help and a happy winters solstice eve to all.

toenail?

step out of line

Step out of line would fit the sense but does not fit the letter pattern....

it is 'step out of line'- check your down answers that cross.....

thank you both so much, the obvious ones are the most elusive sometimes!