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3/4 through and stuck.
8d Road race could make sinners of the winners! (8) M?S?R???
16a Healthy island for a jazz player (7) G?O?M??
21d Puncture in wrecked car could kill you (7) C???E??
29a Driving force from which Americans take the lead (8) ???O?I?E
Any pointers appreciated.

car+hole- cholera?

16: (Benny) GOODMAN

good man?

Healthy = good
Island = Man
Goodman - jazz player

8d road is M1+ another word for race/dash

gasoline? (take the lead as in lead free?)

My apologies, you asked for pointers and I provided the answers. Sorry.

I'm thinking miseries for the first - mi road, and race could be series. But why sinners out of winners? No idea

the race is another word for a short dash, running quickly, the answer reflects the clue (typing an s not w would be one of these).
I am stuck on 10a and 18 d. Any help available?